In an exclusive MTV News Q&A, the actor talks about his current and upcoming projects... and shirtless Justin Bieber.
By Josh Horowitz
Source: http://www.mtv.com/news/articles/1706426/matthew-mcconaughey-mud-magic-mike-sequel.jhtml
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JERUSALEM (AP) ? Israel's prime minister on Monday said that Iran is steadily edging closer to nuclear weapons capability but has not yet reached the "red line" he drew in a speech to the United Nations last fall.
Benjamin Netanyahu delivered his assessment as Israel took delivery of the fifth of six advanced submarines it has ordered from Germany. The "Dolphin" class vessels are believed to be capable of carrying missiles with nuclear warheads and could play an important role in any future conflict between Israel and Iran.
In Iran, an influential former president appeared to be trying to lower tensions with Israel, saying that his country is not at war with the Jewish state, Iranian media reported. It was the latest departure by a high-profile politician from the strident anti-Israel line traditionally taken by senior Iranian leaders.
The remarks by Akbar Hashemi Rafsanjani follow calls from figures across his nation's political spectrum to repair the damage to Iran's international reputation, blaming outgoing President Mahmoud Ahmadinejad, who called Israel a doomed state and questioned the extent of the Holocaust.
Several of the critics, including Rafsanjani, are considered possible contenders in June elections to succeed Ahmadinejad.
"We are not at war with Israel," said the ex-president, quoted by several Iranian newspapers including the pro-reform Shargh daily. He said Iran would not initiate war against Israel, but "if Arab nations wage a war, then we would help."
Israel accuses Iran of trying to develop nuclear weapons, a suspicion shared by much of the world. The international community has imposed a series of economic sanctions on Iran and opened a dialogue with the Tehran regime, but so far has failed to curb its nuclear program. Iran says its program is for peaceful purposes only.
Israel says a nuclear-armed Iran would threaten Israel's existence, citing Iranian calls for Israel's destruction and its development of sophisticated missiles capable of striking Israel. Netanyahu has repeatedly hinted that Israel would be prepared to attack Iran, unilaterally if necessary, if the international pressure fails to stop the Iranian nuclear program.
Speaking to his Likud Party on Monday, Netanyahu warned that the Iranian program continues to advance.
"It has not yet crossed the red line that I presented at the U.N., but is systematically getting closer to it," he said. "We cannot let (Iran) cross it."
In his speech to the U.N. General Assembly last September, Netanyahu said the international community would have until mid-2013 to stop Iran from producing a bomb. He said in a television interview this month that Iran has already produced 170 kilograms of the 250 kilograms of enriched uranium needed to be capable of building a bomb. He said his assessment was based on figures from the U.N. nuclear agency.
A key Netanyahu rival, former Prime Minister Ehud Olmert, accused some Israelis of exaggerating the threat posed by Iran's nuclear program and strongly hinted that covert Israeli operations have hindered the Iranians.
Speaking to a New York conference, Olmert noted that a decade ago, intelligence experts predicted that Iran would have nuclear weapons by 2009. "Now we are in the middle of 2013, and they still don't have it," he said. He also said his government "did no less" than any other Israeli government in dealing with the threat.
"They don't have it not only because of their failures. Perhaps someone helped them to fail," Olmert said at Sunday's Jerusalem Post Conference, hinting he was referring to his government.
Israel was widely believed to be involved in mysterious computer viruses that have crippled Iran's nuclear program. Iran has also accused Israel of killing nuclear scientists. Israel does not comment on such issues as a matter of policy.
The U.S. says it shares Israel's commitment to preventing Iran from gaining nuclear weapons. But during a trip to the region earlier this month, Defense Secretary Chuck Hagel acknowledged there are some differences with Israel over when military action might be needed.
The U.S. has said it respects Israel's right to defend itself but urged the Israelis to give more time for diplomacy to work. The U.S. has voiced concerns that a unilateral Israeli strike could draw the U.S. into a region-wide war.
Israel's time frame is shorter because it does not possess the same powerful weaponry as the U.S. During his visit, Hagel stressed the U.S. commitment to preserving Israel's qualitative military edge in the Middle East, listing advanced weapons it would provide. Among them were refueling planes that could be used in long-distance operations such as striking Iran.
On Monday, Israel's military announced the "inauguration" of its fifth Dolphin-class submarine purchased from Germany. In a statement, it said the submarine is expected to arrive in Israel within the next year after its operational systems are completed and installed.
Analysts say the Dolphin can be fitted with missiles carrying nuclear warheads, so that the vessels could provide a "second strike" capability if Iran were to attack Israel with a nuclear weapon. Israel is widely believed to possess nuclear weapons, though it does not confirm or deny having them.
"The submarines are a strong, strategic tool" for Israel, Netanyahu said. "The state of Israel is ready to act anytime, anywhere ? on land, sea and air ? in order to ensure the security of Israel's citizens," he said.
___
Associated Press writer Nasser Karimi in Tehran contributed to this report.
Source: http://news.yahoo.com/israel-iran-not-crossed-nuclear-red-line-182924532.html
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LOS ANGELES (AP) ? Hundreds of personal items, including antiques, artwork and furniture once owned by Bob Hope and his wife, Dolores, will be auctioned to benefit a Southern California charity.
The Daily News of Los Angeles reports (http://bit.ly/11tF2Zk) proceeds from the sale Saturday will help the family service center at St. Charles Borromeo Church in North Hollywood, where Dolores Hope was a member for 70 years.
The couple's daughter, Linda Hope, says memorabilia from Bob Hope's long show business career will also be up for sale.
Prices will range from $10 to several hundred dollars an item.
An auction of additional property from the couple's Toluca Lake estate will be announced by Julien's Auctions of Beverly Hills later this year.
Dolores Hope died in 2011. Bob Hope died in 2003.
___
Information from: (Los Angeles) Daily News, http://www.dailynews.com
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Pilates Method Illustration
When you first start doing Pilates or any other exercise method you learn to do specific exercises. But it is very difficult to work out what these are simply by reading text. It?s far easier to learn such things if you can see illustrations that demonstrate the exercise and show you how and where to place your body.
So where can you find illustrations of those Pilates Method exercises to help you learn what to do?
For those people who are still puzzled about where to find the best Pilates Method illustrations, then I would suggest you to search online. But, where exactly online? Some websites are better than others.
ShapeFit is in the first place the Internet?s premier health and fitness web site. This is run by people who are dedicated to providing the general public with health and fitness related information to lose weight and get in the best shape of their lives.
As part of their service, ShapeFit provides a lot of information regarding the Pilates Method. You will even find that the basics of Pilates are provided, including the history and benefits.
Perhaps what is best about this site is that they present these exercises along with Pilates Method illustrations.
These exercises are categorized according to ability so that newbies know where to start, and those who have had some experience don?t waste time with beginner exercises.. So you?ll soon find the right exercises irrespective of whether you?re a beginner, intermediate, or advanced users.
Along with the Pilates Method illustrations, ShapeFit provides step-by-step instructions for the proper movements. The purpose of exercise and some tips are also provided to better answer to your Pilates needs.
?
Pilates Method Illustration
This is another great site to visit to find Pilates Method illustrations. It appears to be an authentic Pilates Studio well-known for being brand new, well-lighted, clean and fully equipped.
Almost all the necessary Pilates equipment can be found here, including the reformers, Cadillac, wall units, wonder chair, big barrel, mini barrel, and spine collector.
Apart from showing all the equipment used in Pilates,Union Square Pilates presents certain Pilates Method illustrations that best describe not only the movements, but also how the equipment is used.
Here you?ll learn about the right positions for exercises done on the reformer., There are also Pilates Method illustrations for the wunda chair and Cadillac exercises. These illustrations are very well presented.
So if you want to know how great this site is, simply log onto the Internet and see for yourself.
Spine-Health.com is included here to provide you with a comprehensive information resource for understanding the Pilates Method and its exercises. Just like the above mentioned sites, Spine-Health.com also provides comprehensive and clear Pilates Method illustrations of the different Pilates exercises.
Pilates Anytime offer a wide range of Classes from top Instructors. They add new Classes several times a week, from beginners to advanced, all filmed in HD.
You can take classes from the comfort of your home, or wherever life takes you ? on your own schedule.
For just $18 per month you can take as many Classes as you like. Why not take advantage of Pilates Anytime?s FREE 15 day trial?
Rusty comments ??
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Source: http://www.pilates9.com/where-to-find-pilates-method-exercise-illustrations/
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SALT LAKE CITY (AP) ? The Mormon church has given its blessing to the Boy Scouts of America on its latest proposal to lift the gay ban for youth members but continue to exclude gays as adult leaders.
The Church of Jesus Christ of Latter-day Saints posted a statement on its website Thursday saying it is satisfied with the proposal, which the Boy Scouts announced last week and will submit to its National Council at a meeting in Texas the week of May 20.
The Salt Lake City-based church said it is satisfied that the Boy Scouts of America has made a "thoughtful, good-faith effort to address issues that, as they have said, remain 'among the most complex and challenging issues facing the BSA and society today.'"
It added the proposal recognizes that "Scouting exists to serve and benefit youth rather than Scout leaders, a single standard of moral purity for youth in the program, and a renewed emphasis for Scouts to honor their duty to God."
The reaction from the LDS church comes six days after the Boy Scouts of America made its major announcement. The Mormon church has more Scouting troops than any other religious denomination in the country so there was widespread interest in what it would say about the proposal.
The LDS church still teaches its members that marriage is between a man and a woman and that same-sex relationships are sinful. In December, however, the church launched a website encouraging members to be more compassionate in discussions about homosexuality. The website says Mormons should be loving and respectful toward gays and lesbians, while appealing to gay and lesbian Mormons to stay in the church.
It marked the most significant outreach yet to gays and lesbians by the Mormon church, which has about 14 million members worldwide.
The Boy Scouts of America issued a statement Thursday saying the organization is deeply appreciative of its long-standing relationship with the Mormon church and pleased to hear it is satisfied with the proposal. Scouting is successful because of strong relationships with chartered organizations like the Mormon church, the Boy Scouts' statement said.
The latest proposal from the Boy Scouts of America is a compromise on the divisive issue; the organization earlier floated the idea of completely lifting the ban on gays. Gay-rights groups, which had demanded that the ban be removed, have criticized the latest proposal as inadequate.
In making its announcement last week, Boy Scouts of America estimated that easing the ban on gay adults could cause widespread defections that cost the organization 100,000 to 350,000 members.
Utah likely was included in that estimate.
The Boy Scouts' Great Salt Lake Council is one of biggest in country, with 5,500 troops and 73,400 youth. Almost all of those troops are sponsored by the Mormon church.
In a survey the council sent to its members, four out of five Scout leaders and parents said they're opposed to lifting the ban on gays. About 4,700 adults responded to the survey, which the council shared with the Boy Scouts. Nearly half of the respondents said they would quit the Boy Scouts if the ban on gays is lifted.
The Great Salt Lake Council has not yet weighed in on the latest proposal. Members are going to meet to discuss it at their May 8 meeting before coming out with any opinion, said Rick Barnes, executive of the Boy Scouts' Great Salt Lake Council.
___
Follow Brady McCombs at https://twitter.com/BradyMcCombs .
Source: http://news.yahoo.com/mormon-church-pleased-boy-scouts-proposal-223702757.html
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Apr. 25, 2013 ? NASA's Cassini spacecraft has provided the first direct evidence of small meteoroids breaking into streams of rubble and crashing into Saturn's rings.
These observations make Saturn's rings the only location besides Earth, the moon and Jupiter where scientists and amateur astronomers have been able to observe impacts as they occur. Studying the impact rate of meteoroids from outside the Saturnian system helps scientists understand how different planet systems in our solar system formed.
The solar system is full of small, speeding objects. These objects frequently pummel planetary bodies. The meteoroids at Saturn are estimated to range from about one-half inch to several yards (1 centimeter to several meters) in size. It took scientists years to distinguish tracks left by nine meteoroids in 2005, 2009 and 2012.
Details of the observations appear in a paper in the Thursday, April 25 edition of Science.
Results from Cassini have already shown Saturn's rings act as very effective detectors of many kinds of surrounding phenomena, including the interior structure of the planet and the orbits of its moons. For example, a subtle but extensive corrugation that ripples 12,000 miles (19,000 kilometers) across the innermost rings tells of a very large meteoroid impact in 1983.
"These new results imply the current-day impact rates for small particles at Saturn are about the same as those at Earth -- two very different neighborhoods in our solar system -- and this is exciting to see," said Linda Spilker, Cassini project scientist at NASA's Jet Propulsion Laboratory in Pasadena, Calif. "It took Saturn's rings acting like a giant meteoroid detector -- 100 times the surface area of the Earth -- and Cassini's long-term tour of the Saturn system to address this question."
The Saturnian equinox in summer 2009 was an especially good time to see the debris left by meteoroid impacts. The very shallow sun angle on the rings caused the clouds of debris to look bright against the darkened rings in pictures from Cassini's imaging science subsystem.
"We knew these little impacts were constantly occurring, but we didn't know how big or how frequent they might be, and we didn't necessarily expect them to take the form of spectacular shearing clouds," said Matt Tiscareno, lead author of the paper and a Cassini participating scientist at Cornell University in Ithaca, N.Y. "The sunlight shining edge-on to the rings at the Saturnian equinox acted like an anti-cloaking device, so these usually invisible features became plain to see."
Tiscareno and his colleagues now think meteoroids of this size probably break up on a first encounter with the rings, creating smaller, slower pieces that then enter into orbit around Saturn. The impact into the rings of these secondary meteoroid bits kicks up the clouds. The tiny particles forming these clouds have a range of orbital speeds around Saturn. The clouds they form soon are pulled into diagonal, extended bright streaks.
"Saturn's rings are unusually bright and clean, leading some to suggest that the rings are actually much younger than Saturn," said Jeff Cuzzi, a co-author of the paper and a Cassini interdisciplinary scientist specializing in planetary rings and dust at NASA's Ames Research Center in Moffett Field, Calif. "To assess this dramatic claim, we must know more about the rate at which outside material is bombarding the rings. This latest analysis helps fill in that story with detection of impactors of a size that we weren't previously able to detect directly."
The Cassini-Huygens mission is a cooperative project of NASA, the European Space Agency and the Italian Space Agency. NASA's Jet Propulsion Laboratory, Pasadena, Calif., a division of the California Institute of Technology, Pasadena, manages the Cassini-Huygens mission for NASA's Science Mission Directorate in Washington. JPL designed, developed and assembled the Cassini orbiter and its two onboard cameras. The imaging team consists of scientists from the United States, England, France and Germany. The imaging operations center is based at the Space Science Institute in Boulder, Colo.
For images of the impacts and information about Cassini, visit: http://www.nasa.gov/cassini and http://saturn.jpl.nasa.gov .
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/SgDGsVxA4wQ/130425144654.htm
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Public release date: 25-Apr-2013
Share ] Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
LEXINGTON, Ky. (April 25, 2013) A unique new study led by University of Kentucky Markey Cancer Center researchers Guo-Min Li and Libya Gu, in collaboration with Dr. Wei Yang at National Institutes of Health, reveals a novel mechanism explaining the previously unknown root cause of some forms of colorectal cancers.
The study, published in Cell, discovers that an abnormal histone protein modification impairs a DNA repair machinery that controls cancer development, yielding a potential new way of detecting these types of colorectal cancers. It represents the first time that epigenetic histone marks regulate the genome maintenance system.
DNA errors created during DNA replication can lead to many forms of cancer, including colorectal cancer. Cells possess DNA mismatch repair (MMR) machinery that aids in correcting these errors, thus preventing disease development. Defects in MMR genes lead to development of colorectal cancers characterized by frequent alterations in simple repetitive DNA sequences, a phenomenon referred to as microsatellite instability (MSI). Some cancers develop in individuals who possess MSI without MMR gene defects, and until now, the reason for this has been unknown.
Dr. Li's study shows that defects in SETD2 an enzyme that is not involved in MMR but chemically or epigenetically modifies histone proteins associated with DNA that control the regulation of gene expression and DNA replication prevent the association of MMR proteins with damaged DNA, thus preventing DNA mismatch repair.
"This study provides new clues to cancer etiology, that is, from the classical genetic defects to abnormal epigenetic modifications in the future," Li said. "Since SETD2 mutations have been shown in many types of cancers, including clear cell renal cell carcinoma, lung cancer, gastric cancer and hematological malignancies, our next goal is to determine association of MMR defects with these cancers, as well as SETD2 mutations in MSI-positive MMR-competent colorectal cancers."
Although most colorectal cancers are preventable or treatable with proper screening, colorectal cancer remains the second-leading cause of cancer death in the United States. Kentucky is ranked in the highest tiers for both colorectal and lung cancer incidence and death.
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 25-Apr-2013 Share ] Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
LEXINGTON, Ky. (April 25, 2013) A unique new study led by University of Kentucky Markey Cancer Center researchers Guo-Min Li and Libya Gu, in collaboration with Dr. Wei Yang at National Institutes of Health, reveals a novel mechanism explaining the previously unknown root cause of some forms of colorectal cancers.
The study, published in Cell, discovers that an abnormal histone protein modification impairs a DNA repair machinery that controls cancer development, yielding a potential new way of detecting these types of colorectal cancers. It represents the first time that epigenetic histone marks regulate the genome maintenance system.
DNA errors created during DNA replication can lead to many forms of cancer, including colorectal cancer. Cells possess DNA mismatch repair (MMR) machinery that aids in correcting these errors, thus preventing disease development. Defects in MMR genes lead to development of colorectal cancers characterized by frequent alterations in simple repetitive DNA sequences, a phenomenon referred to as microsatellite instability (MSI). Some cancers develop in individuals who possess MSI without MMR gene defects, and until now, the reason for this has been unknown.
Dr. Li's study shows that defects in SETD2 an enzyme that is not involved in MMR but chemically or epigenetically modifies histone proteins associated with DNA that control the regulation of gene expression and DNA replication prevent the association of MMR proteins with damaged DNA, thus preventing DNA mismatch repair.
"This study provides new clues to cancer etiology, that is, from the classical genetic defects to abnormal epigenetic modifications in the future," Li said. "Since SETD2 mutations have been shown in many types of cancers, including clear cell renal cell carcinoma, lung cancer, gastric cancer and hematological malignancies, our next goal is to determine association of MMR defects with these cancers, as well as SETD2 mutations in MSI-positive MMR-competent colorectal cancers."
Although most colorectal cancers are preventable or treatable with proper screening, colorectal cancer remains the second-leading cause of cancer death in the United States. Kentucky is ranked in the highest tiers for both colorectal and lung cancer incidence and death.
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/uok-uss042513.php
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Public release date: 25-Apr-2013 Share ] Contact: Daniel Fowler
pubinfo@asanet.org
202-527-7885
American Sociological Association
WASHINGTON, DC, April 25, 2013 Global attitudes about domestic violence changed dramatically during the first decade of the 2000s, according to a new University of Michigan study that analyzes data from 26 low- and middle-income countries.
Nigeria had the largest change, with 65 percent of men and 52 percent of women rejecting domestic violence in 2008, compared with 48 percent and 33 percent, respectively, in 2003.
In the study, which appears in the April issue of the American Sociological Review, University of Michigan researcher Rachael Pierotti analyzes data on hundreds of thousands of people collected in Demographic and Health Surveys funded by the United States Agency for International Development (USAID). Half of the countries surveyed are in sub-Saharan Africa.
"In many countries, men were even more likely to reject violence than women were," says Pierotti, a graduate student in sociology.
Data on male attitudes was available in 15 of the countries Pierotti studied. Men were more likely than women to reject domestic violence in Benin, Ethiopia, Ghana, Indonesia, Madagascar, Malawi, Nigeria, Rwanda, Tanzania, Uganda, and Zambia.
The survey questions about attitudes toward domestic violence differed slightly from one country to another. But the most common form was as follows:
Sometimes a husband is annoyed or angered by things which his wife does. In your opinion, is a husband justified in hitting or beating his wife in the following situations?
In general, Pierotti found that people were most likely to say that violence was justified if a wife neglected the children and least likely to consider it justifiable if a wife burned the food.
In two countries Madagascar and Indonesia attitudes among both men and women changed in the wrong direction. During the period studied, the percentage of men and women rejecting domestic violence decreased in those countries.
Pierotti found that attitudes about the use of domestic violence changed significantly among all age groups. "Often it's the case that social change starts with younger people," she says. "But in this case, people of all ages became more rejecting of domestic violence."
She found that those who lived in urban areas, and who had more education, were more likely to reject wife beating than those who lived in rural areas and who had relatively less education. She also found that in many of the countries, those with access to newspapers, radio, and television were more likely to reject wife beating.
"The global spread of ideas about women's rights and the increasing international attention to the problem of violence against women may be contributing to the striking change in attitudes about this issue," says Pierotti. "But more research will be needed in order to confirm if this is really the reason."
Pierotti is the winner of a Marshall Weinberg Research Fellowship at the University of Michigan Institute for Social Research (ISR) Population Studies Center and this work was supported by a National Science Foundation (NSF) Graduate Research Fellowship.
###
About the American Sociological Association and the American Sociological Review
The American Sociological Association, founded in 1905, is a non-profit membership association dedicated to serving sociologists in their work, advancing sociology as a science and profession, and promoting the contributions to and use of sociology by society. The American Sociological Review is the ASA's flagship journal.
The research article described above is available by request for members of the media. For a copy of the full study, contact Daniel Fowler, ASA's Media Relations and Public Affairs Officer, at (202) 527-7885 or pubinfo@asanet.org.
For more information about the study, members of the media can also contact Diane Swanbrow, University of Michigan, at (734) 647-9069 or swanbrow@umich.edu.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 25-Apr-2013 Share ] Contact: Daniel Fowler
pubinfo@asanet.org
202-527-7885
American Sociological Association
WASHINGTON, DC, April 25, 2013 Global attitudes about domestic violence changed dramatically during the first decade of the 2000s, according to a new University of Michigan study that analyzes data from 26 low- and middle-income countries.
Nigeria had the largest change, with 65 percent of men and 52 percent of women rejecting domestic violence in 2008, compared with 48 percent and 33 percent, respectively, in 2003.
In the study, which appears in the April issue of the American Sociological Review, University of Michigan researcher Rachael Pierotti analyzes data on hundreds of thousands of people collected in Demographic and Health Surveys funded by the United States Agency for International Development (USAID). Half of the countries surveyed are in sub-Saharan Africa.
"In many countries, men were even more likely to reject violence than women were," says Pierotti, a graduate student in sociology.
Data on male attitudes was available in 15 of the countries Pierotti studied. Men were more likely than women to reject domestic violence in Benin, Ethiopia, Ghana, Indonesia, Madagascar, Malawi, Nigeria, Rwanda, Tanzania, Uganda, and Zambia.
The survey questions about attitudes toward domestic violence differed slightly from one country to another. But the most common form was as follows:
Sometimes a husband is annoyed or angered by things which his wife does. In your opinion, is a husband justified in hitting or beating his wife in the following situations?
In general, Pierotti found that people were most likely to say that violence was justified if a wife neglected the children and least likely to consider it justifiable if a wife burned the food.
In two countries Madagascar and Indonesia attitudes among both men and women changed in the wrong direction. During the period studied, the percentage of men and women rejecting domestic violence decreased in those countries.
Pierotti found that attitudes about the use of domestic violence changed significantly among all age groups. "Often it's the case that social change starts with younger people," she says. "But in this case, people of all ages became more rejecting of domestic violence."
She found that those who lived in urban areas, and who had more education, were more likely to reject wife beating than those who lived in rural areas and who had relatively less education. She also found that in many of the countries, those with access to newspapers, radio, and television were more likely to reject wife beating.
"The global spread of ideas about women's rights and the increasing international attention to the problem of violence against women may be contributing to the striking change in attitudes about this issue," says Pierotti. "But more research will be needed in order to confirm if this is really the reason."
Pierotti is the winner of a Marshall Weinberg Research Fellowship at the University of Michigan Institute for Social Research (ISR) Population Studies Center and this work was supported by a National Science Foundation (NSF) Graduate Research Fellowship.
###
About the American Sociological Association and the American Sociological Review
The American Sociological Association, founded in 1905, is a non-profit membership association dedicated to serving sociologists in their work, advancing sociology as a science and profession, and promoting the contributions to and use of sociology by society. The American Sociological Review is the ASA's flagship journal.
The research article described above is available by request for members of the media. For a copy of the full study, contact Daniel Fowler, ASA's Media Relations and Public Affairs Officer, at (202) 527-7885 or pubinfo@asanet.org.
For more information about the study, members of the media can also contact Diane Swanbrow, University of Michigan, at (734) 647-9069 or swanbrow@umich.edu.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/asa-srd042513.php
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Current president and CEO of Nintendo Co., Ltd. Saturo Iwata was just given a new gig by his struggling employer. In addition to the roles he already has, Iwata will now assume the position of CEO of Nintendo of America (NoA), replacing current chief executive and chairman Tatsumi Kimishima, who is transferring to the company's Kyoto headquarters to serve as the General Manager of both the Corporate Analysis and Administration as well as the General Affairs Division.
Iwata will now oversee NoA president and Chief Operating Officer Reggie Fils-Aime. His and Kimishima's new appointments are just one part of an executive-level reshuffling for Nintendo's board of directors as several key members plan to retire.
In a statement announcing the new appointments, Nintendo said the move will support "the company's unified global strategy" and "allow streamlined decision making and enhance Nintendo's organizational agility in the current competitive environment."
Nintendo announced the executive shifts alongside its 2013 fiscal year earnings report, which saw the company return to profitability after posting its first loss in three decades the previous year.
The news is hardly encouraging for the world's largest video game console maker, however. Nintendo reported a net profit of ?7.10 billion ($71.7 million) for the year ended in March, up from a loss of ?43.20 billion in the previous year but nearly half the company's projected ?14 billion.
Much of this income gap stems from lower-than-expected sales of its new home entertainment console, the Wii U, which was first released last November. The company announced that just 3.45 million Wii U units have shipped worldwide so far?more than half a million units short of its January forecast for 4 million, which was itself a diminished forecast from the original 5.5 million projection. These figures imply that the Wii U only shipped an additional 390,000 units globally in the last three months.
The company predicted that net income will rise to ?55 billion yen in the fiscal year ending March 31, 2014, saying that it expects to sell 9 billion Wii U consoles in the coming year. Analysts, however, have remained wary about the console's commercial prospects as it faces increased competition from competitors like Sony and Microsoft ? both of which are expected to release next-generation gaming devices of their own in time for the 2013 holiday season.
Michael Pachter, an analyst at Wedbush Securities who told NBC News last week in no uncertain terms that he thinks Iwata "sucks" at his job, said the Wii U is "just a baffling thing" that disregards the very interests of the home console market to which it is meant to appeal.
"I've always said that I think they came up with a solution and never identified the problem that they were solving," Pachter said.
"And the proof of that is: how many people call it a tablet when it first came out?" he added, referring to the large touchscreen controller officially known as a "GamePad" that comes with the device.
Pachter didn't doubt the attraction that many gamers still feel to beloved Nintendo game franchises like "Super Mario Bros." and "The Legend of Zelda," but he felt that the fact that Nintendo had to release a separate Xbox 360-style "Wii U Pro" controller showed that the company no longer knows how to appeal to many of the gamers would be willing to make a hefty investment into a new console.
And without a guaranteed audience of dedicated console gamers like Sony or Microsoft has, the company risks losing its already tenuous third-party support to make new games for the Wii U.
"It doesn't appear they're going to get long-lasting third party support," Pachter said. "The ones that did support are going to abandon it if it doesn't sell better," presumably once the PlayStation 4 or new Xbox can offer developers a larger customer base than the Wii U can.
Without that third-part support, Nintendo is left with its many "Mario" and "Zelda" franchises, which have certainly done enough to support the 3DS, but not necessarily an additional console ? and a pricier one at that.
"None of us can figure out why exactly we want one," Pachter said. "We don't need a home console that's like the 3DS, and that's just what the Wii U is."
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Public release date: 24-Apr-2013 Share ] Contact: Erin White
ewhite@northwestern.edu
847-491-4888
Northwestern University
CHICAGO --- With the help of genetics, prostate specific antigen (PSA) screenings may become more accurate and reduce the number of unnecessary prostate biopsies, according to a new study from Northwestern Medicine.
Personalized PSA testing using genetic variants could account for an 18 percent reduction in the number of men who likely would have undergone unnecessary biopsies, according to the study. It will be published in the May 2013 issue of The Journal of Urology.
The high survival rate of men with prostate cancer is largely a reflection of PSA testing, but support for the widespread use of the screening method has been the topic of recent debate because of its limited specificity.
"By utilizing a person's genetic makeup we can personalize care when he comes in for a PSA screening," said Brian Helfand, M.D., lead author of the study. "We may be able to prevent some men from having an unnecessary biopsy and prevent a delay in biopsy for men who may have an aggressive disease."
Helfand is an adjunct assistant professor of cell and molecular biology at Northwestern University Feinberg School of Medicine.
For 98 percent of the men, genetic adjustment of PSA levels did not change the outcome of their screening. But genetic correction was important for the 17 men who were reclassified as no longer meeting biopsy criteria and the three whose condition was up classified, and it was recommended they get a biopsy, based on their genetic adjustment.
"If our results are validated, genetic adjustments could potentially prevent 15 to 20 percent of prostate biopsies," said William J. Catalona, M.D., senior author of the study. "Since it has been estimated that more than 1 million biopsies are performed in the United States annually, this could translate into 150,000 to 200,000 potentially unnecessary biopsies every year."
In addition to cost savings, fewer biopsies mean fewer adverse outcomes, such as infection, sepsis and hospitalization, he said.
Catalona is a professor of urology at Feinberg, director of the clinical prostate cancer program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and an urologist at Northwestern Memorial Hospital.
Variants in genes, like those that help determine your height, are responsible for higher or lower levels of PSA expression. Recent studies have identified genetic variants associated with increased serum PSA concentrations, raising the possibility that a man's genetic make-up could interfere with an accurate PSA reading.
In this study, four variants previously associated with PSA levels were determined in 964 Caucasian volunteers without prostate cancer. Genetic correction of their PSA was performed by dividing each man's PSA value by his combined genetic risk. Analyses were used to compare the percentage of men who would meet commonly used biopsy thresholds (2.5 ng/ml or greater, or 4.0 ng/ml or greater) before and after genetic correction.
Assuming that a diagnostic laboratory has the available equipment, supplies and trained personnel, it would cost 60 cents per person to add genetic personalization to a PSA test.
The researchers are now investigating personalized PSA testing in black men and have plans to investigate genetic variants which impact PSA levels in other races as well.
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 24-Apr-2013 Share ] Contact: Erin White
ewhite@northwestern.edu
847-491-4888
Northwestern University
CHICAGO --- With the help of genetics, prostate specific antigen (PSA) screenings may become more accurate and reduce the number of unnecessary prostate biopsies, according to a new study from Northwestern Medicine.
Personalized PSA testing using genetic variants could account for an 18 percent reduction in the number of men who likely would have undergone unnecessary biopsies, according to the study. It will be published in the May 2013 issue of The Journal of Urology.
The high survival rate of men with prostate cancer is largely a reflection of PSA testing, but support for the widespread use of the screening method has been the topic of recent debate because of its limited specificity.
"By utilizing a person's genetic makeup we can personalize care when he comes in for a PSA screening," said Brian Helfand, M.D., lead author of the study. "We may be able to prevent some men from having an unnecessary biopsy and prevent a delay in biopsy for men who may have an aggressive disease."
Helfand is an adjunct assistant professor of cell and molecular biology at Northwestern University Feinberg School of Medicine.
For 98 percent of the men, genetic adjustment of PSA levels did not change the outcome of their screening. But genetic correction was important for the 17 men who were reclassified as no longer meeting biopsy criteria and the three whose condition was up classified, and it was recommended they get a biopsy, based on their genetic adjustment.
"If our results are validated, genetic adjustments could potentially prevent 15 to 20 percent of prostate biopsies," said William J. Catalona, M.D., senior author of the study. "Since it has been estimated that more than 1 million biopsies are performed in the United States annually, this could translate into 150,000 to 200,000 potentially unnecessary biopsies every year."
In addition to cost savings, fewer biopsies mean fewer adverse outcomes, such as infection, sepsis and hospitalization, he said.
Catalona is a professor of urology at Feinberg, director of the clinical prostate cancer program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and an urologist at Northwestern Memorial Hospital.
Variants in genes, like those that help determine your height, are responsible for higher or lower levels of PSA expression. Recent studies have identified genetic variants associated with increased serum PSA concentrations, raising the possibility that a man's genetic make-up could interfere with an accurate PSA reading.
In this study, four variants previously associated with PSA levels were determined in 964 Caucasian volunteers without prostate cancer. Genetic correction of their PSA was performed by dividing each man's PSA value by his combined genetic risk. Analyses were used to compare the percentage of men who would meet commonly used biopsy thresholds (2.5 ng/ml or greater, or 4.0 ng/ml or greater) before and after genetic correction.
Assuming that a diagnostic laboratory has the available equipment, supplies and trained personnel, it would cost 60 cents per person to add genetic personalization to a PSA test.
The researchers are now investigating personalized PSA testing in black men and have plans to investigate genetic variants which impact PSA levels in other races as well.
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/nu-ppc042413.php
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